Organoids – mini organs or tissues grown in the lab from relevant cells or stem cells – are powerful models for dissecting the characteristics, genetics and interactions that make up the real-life setting, commonly far too big and developed to track in real time or consider as a whole. Here, human pluripotent stem cells have been manipulated to grow as an organoid to mimic the early spinal cord and a key role revealed for a protein called YAP in shaping the cord's inner space or lumen (part of the cord's natural developmental process)
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