Leading to Vessels

As new blood vessels develop (a process known as angiogenesis) – whether when building an embryo or in tissue repair or disease – the individual vessel cells (endothelia) must migrate and join, forming junctions between leaders and followers. Here, using 3D super-resolution microscopy, the ultrastructure of these asymmetric adherens junctions are revealed and how proteins BIN1 and SNX9 regulate the front-to-rear polarity in follower cells to guide angiogenesis. The video shows endothelial cells migrating in developing zebrafish, deregulated (right) by blocking SNX9 and unblocked (left)

Read the published research article here

Written by Lindsey Goff

Lindsey Goff

Editor-in-Chief

Formerly immunologist for Cancer Research UK, Lindsey has since moved into the field of scientific publishing. She looks after all BPoD editorial matters.

• Video from work by Vera Janssen and colleagues
• Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, The Netherlands
• Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
• Published in Journal of Cell Biology, July 2026