Damage to cells of the skin's outer layer, the cells covering organs and the gut's inner lining, and elsewhere – in other words the epithelial cells – triggers inflammation. This study in fruit flies shows that their version (Tep3) of the human protein CD109 produced in wounds and tumours limits immune cells called macrophages at the inflammatory site, and that raised Tep3 in fly cancers reduces the macrophage-dependent anti-tumour immune response, thereby protecting the tumour, harming the host
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