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22 January 2026
Visualing Function
Here, imaging-based CRISPR screening of the genome (to mutate genes of interest), allows cell-regulating molecules and modifications to be revealed in live and fixed cells. Primary cilia – whiskery functional projections found on most cell types – are studied here as a proof of concept and several previously unknown ciliary regulators identified and characterised, such as microprotein TZMP1. Shown are tadpole skin cells with cilia – left, unmanipulated and right, after CRISPR-targeting the gene encoding TZMP1
Read the published research article here
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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
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