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04 May 2026

Early to Rise

Cajal-Retzius cells are a multifunctional cell type involved in the development of mammals' cortex – the brain region that sets mammals apart from other animal classes. But are they only found in mammals or have they acquired their mammal-specific function through evolution from earlier species? Comparing the activity of genes in single cells and cell location in a bird, amphibian, bony (shown here) and cartilaginous fish species, this study concludes that Cajal-Retzius cells existed at least in the last common ancestor of jawed vertebrates and underwent changes in the mammalian line of evolution.

Read the published research article here

Written by Lindsey Goff

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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