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26 April 2026
Manichaean Moments
What are the the defining events as cells transition from benign behaviour to becoming cancer? In mouse models of the most common pancreatic cancer (PDAC) and in human pancreatic tissue, using single cell analysis and gene activity mapping of tissue (spatial transcriptomics) this study finds a balance between oncogenic KRAS (a protein with cancer-inducing potential) activation promoting a cancer-like niche for progenitor cells and tumour-suppressing p53 pathways which act to destroy this niche and restore stability. Such a state of plasticity presents new possibilities for cancer therapeutic interventions
Read the published research article here
Written by
- Image from work by José Reyes and colleagues
- Cancer Biology and Genetics Program and Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Cell, April 2026
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