02 June 2025
Mechanism of Malformation
Cerebral cavernous malformation (CCM) – a lesion of misshaped blood vessel growth in the brain present from birth – results from mutations in the KRIT1 gene (amongst others). Using induced pluripotent stem cells (iPSCs) derived from patient tissue, this study traces how mutated KRIT1 leads to the malformation
Read the published research article here
Written by
- Still from video from work by Maximiliano Arce and colleagues
- Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
- Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Cell Reports, May 2025
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