16 December 2024
Letting in Blood
Encouraging cells in the skin's connective tissue called fibroblasts to turn into blood vessels is an ambition for restoring blood flow to limbs damaged by diabetes. This study finds that while delivering a cocktail of genes to fibroblasts will promote vascularisation, an epigenetic change called gene demethylation regulated by a protein family called TET1/2/3 is necessary to achieve vascularisation in live animals
Read the published research article here
Written by
- Still from video from work by Sujit K. Mohanty and Kanhaiya Singh, and colleagues
- McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
- Video originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)
- Published in Nature Communications, November 2024
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