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27 November 2025
In Zone 3
In the normal liver, a gradient in activity of a molecular signalling pathway called WNT keeps liver cell gene expression and growth distinct in different zones (zonation) from outer to inner tissue – around the liver lobule centre vein being zone 3. This study analyses the complexities of WNT-driven growth and differentiation during tumour development in the liver, and reveals that in the context of cancer-associated gene mutations, the WNT-high zone 3 liver cell state doesn't allow WNT-driven oncogenic growth, providing insights into how cancer develops and may be prevented or treated
Read the published research article here
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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
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