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29 October 2025
Damaged Nucleus Fallout
Heart muscle cells [cardiomyocytes] are continuously contracting then relaxing – mechanical stresses requiring specialised activity of their cytoskeleton and nucleus. This study quantifies the interaction between cardiomyocyte contraction and nuclear deformation, disclosing the nucleus-damaging mechanism underlying – and a potential treatment target for – a type of heart condition called LMNA cardiomyopathy
Read the published research article here
Written by
- Image from work by Daria Amiad Pavlov and Julie Heffler, and colleagues
- Weill Institute for Cell and Molecular Biology & Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY; Dept of Physiology, Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, PA, USA
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Nature Cardiovascular Research, October 2025
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