30 June 2025
Inaction on Interaction
Acute myeloid leukaemia (AML) is a cancer originating from blood cell-forming progenitors of the bone marrow (BM). Unlike normal blood progenitors which polarise towards (thus changing shape) to engage with the nurturing BM substrate or stromal cells (the site known as the niche), AML cells interact with, but their contents fail to polarise towards, the niche. This finding has possible prognostic and therapeutic significance and implies an important role for polarisation in the normal state
Read the published research articles here
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- Image from work by Khansa Saadallah and colleagues
- CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité Paris, France
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in EMBO Reports, June 2025
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