26 June 2025
Deadly Ascent
Spread of breast cancer to the brain is a fatal complication in advanced disease. This study in zebrafish finds that, avoiding the blood-brain barrier, breast cancer cells can migrate along the outside (abluminal) of blood vessels to the brain facilitated by overactivity of a potentially targetable molecular signalling pathway called the Reelin-LRP8-CDC42 axis
Read the published research article here
Written by
- Image from work by Haofeng Huang, Min Zhang & Enyu Huang, and colleagues
- Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in EMBO Molecular Medicine, June 2025
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