Answering questions like "how many genetically transformed (with gene mutations associated with becoming cancerous) cells does it take to form a detectable tumour?" and "how frequently do such screen-obvious tumours transition to become clinically apparent and symptomatic" is of great importance to establish the benefits or risks of cancer screening. Here, in a breast cancer mouse model, researchers track the early cell to screen-detectable lesion and then the next stage to becoming lethal cancer. They reveal that the step from genetically transformed to screen-detectable lesion is rare, and that spread doesn't necessarily correlate with growth rate
Read the published research article here
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