Enhancing polarised light microscopy with a butterfly wing reveals greater detail in fibrous biological tissues
Fluttering around tropical forests of Costa Rica, Morpho butterflies shimmer in shades of blue thanks to tiny structures on their wings. Their scales bend or refract light in different patterns – appearing to change colour as they tilt and twist in the sun. This iridescence is beautiful, but also useful in surprising ways. Light is also changed when shining down through human tissue samples on a microscope, although the subtle differences brought by thicker, cancerous tissue are often difficult to spot. Researchers find bouncing this light off a Morpho wing exaggerates the elliptical polarisation created in breast cancer samples, allowing these samples to be identified more easily. While Morpho wings may not be available to every lab, the technique may inspire new approaches to use structural colour to tease apart differences between healthy and tissue thickened by cancer, fibrosis or heart disease.
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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
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