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01 December 2025
Controlling the Folding
This study analyses the fine details (at the resolution of the G-C and A-T base pairs) of the DNA molecule and its interactions that ultimately bring about the production of proteins from the genetic code. Using molecular dynamics simulations and super-resolution microscopy, researchers here produce a model of how the structure of chromatin (how DNA + proteins exist efficiently packaged) brings about activation of non-gene coding DNA regions called cis-regulatory elements which regulate the transcription or 'reading' of genes
Read the published research article here
Written by
- Adapted from a video from work by Hangpeng Li and colleagues
- MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
- Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Cell, November 2025
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