Crossing the Node

Nerve axons – slender projections, the route of signals from neurons to other cells – are insulated with a sheath called myelin to ensure signals stay on track, however, there are specialised gaps in the wrapping at Nodes of Ranvier which aid signal conduction. This study, using time-lapse microscopy in live mice, investigates how these nodes impact the essential transport of neurons' contents such as mitochondria (highlighted here in cyan) and endosomes (in magenta) along the axons, providing insight into nerve function in health, injury and disease

Read the published research article here

Written by Lindsey Goff

Lindsey Goff

Editor-in-Chief

Formerly immunologist for Cancer Research UK, Lindsey has since moved into the field of scientific publishing. She looks after all BPoD editorial matters.

• Image from work by Andrew P. Tosolini and colleagues
• Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, Queen Square Institute of Neurology, University College London, UK
• Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
• Published in iScience, October 2024