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Bioprobe for detecting subarachnoid haemorrhage, a severe kind of stroke

04 June 2023

Bright Blood

Finding a leak and checking how much water is escaping is key to understanding the problem and preventing damage to your home. Researchers looking at subarachnoid haemorrhage – SAH, a severe type of stroke caused by bleeding from a ruptured vessel on the brain surfaces – need a better way to assess bleeding in experiments with mice. Their current techniques are not sensitive enough to track minor bleeding in mice with SAH, but understanding how this bleeding ultimately causes such lethal damage is important for developing novel treatments. A new approach uses a probe called TTVP, which is clear when dissolved in water but shines brightly under a UV light when blood is added (as shown here). It binds to proteins in blood and points the way to the rupture, helping researchers measure the flow, assess how the damage is caused, and test the impact of new treatments.

Written by Anthony Lewis

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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