Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Life Cycle

Details of protein regulation during the cell cycle revealed – implications for understanding cancers

07 April 2021

Life Cycle

Cell division is an essential process underpinning the development, maintenance and repair of our tissues. Collectively forming the cell cycle, the stages of cell division are shown here in a montage of microscopy images: from left to right, a dividing cell’s nuclear DNA (in blue) condenses into chromosomes, later pulled apart by a network, or spindle, of fibres called microtubules (in red), ultimately forming new nuclei in two daughter cells. Uncontrolled cell division leads to cancer, so understanding cell cycle regulation is critical. To that end, researchers have mapped the changes in protein expression across the cell cycle, using a combination of microscopy and sequencing techniques. Highlighting the complexity of human cells, they found that around 20% of all proteins varied in their level of expression between genetically-identical cells. They also identified over 300 new proteins associated with the cell cycle, providing an abundance of leads for future research.

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at with translations by the University of Valencia.