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05 October 2026
Vessel-damaging Pathways
Errors in development of lymphatic vessels – the body-wide immune system and fluid drainage highway– cause debilitating complex disorders. A mutated variant of the Kras gene called KrasG12D, which is also implicated in cancer, underlies lymphatic vessel abnormalities, and here KrasG12D is revealed to drive two distinct pathways that cause abnormal lymphatic vessel enlargement or disruption of lymphatic valve formation. Pictured are lymphatic vessels in mouse embryo skin
Read the published research article here
Written by
- Image from work by Lorenzo M. Fernandes and Jeffrey Tresemer, and colleagues
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, TX, USA
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in and on the cover of Disease Models & Mechanisms, August 2026
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