25 September 2025
Another Wily Way
HIV has many known means of subverting the immune system to evade destruction. Here, another strategy has been uncovered – HIV-1 mutes a molecule (that normally alerts immune attack) called CD96 on the surface of infected CD4 T cells (the prime target for HIV infection). HIV's proteins Nef and Vpu impede CD96 trafficking and render it susceptible to degradation by the cell's lysosomal 'waste disposal system'
Read the published research article here
Written by
- Image from work by Sandra Dehn and Rabea Burkhard, and colleagues
- Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Science Advances, September 2025
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