 
	
	
 
		Calcium (Ca2+)signalling is a measure of electrical activity or firing in neurons. Here, a multimodal microscope has been developed to simultaneously observe neuron Ca2+) signals, total haemoglobin and blood flow velocity in the brain's cortex of awake, behaving (not necessarily being good, just 'being') mice so that the coupling of vascular and nervous activity, dysregulated in many neurodegenerative diseases such as Parkinson's and Alzheimer's, can be closely followed
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