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Vessels of the eye analysed in development and disease using light-sheet fluorescence microscopy

13 February 2023

Beautiful Eyes

If you look at a clear blue sky it’s possible to see the blood vessels in your own eyes. But researchers demanding a closer look have been working on ways to visualise the full complex network of vessels that permeate our eyeballs. Previous genetic and experimental attempts in mice have tended to look at one sub-section of vessels at a time. A new approach has represented the complete vasculature of the mouse eye at various stages of development (video, with different sections of vasculature digitally coloured). A process to make the eye material transparent is followed by high resolution microscopy and digital analysis. With this technique, the researchers observed how the iris vasculature (yellow) is remodelled during development just after disconnection from the early supply network. They also analysed the impact of injury on vascularisation, showing the platform’s potential for analysing eye disease impacts and treatments on a whole-eye scale.

Written by Anthony Lewis

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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