BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Label-free imaging of intact brain organoids tracks early brain development in cells derived from normal and Rett syndrome-affected tissue

27 August 2022

No Labels Allowed

Investigating diseases that affect an organ as complex as the brain is a challenge; one met using lab-grown brain replicas called brain organoids. However, these organoids are difficult to image due to their thickness. Researchers now present a solution – label-free, 3-photon microscopy – to image brain organoids at greater depths (pictured). This approach generates a special signal that penetrates deep within tissues and highlights cells without needing to label them. First, the team created organoids using human induced pluripotent stem cells from healthy patients or those with the brain disease Rett syndrome. Imaging deep within the organoids revealed that an area called the ventricular zone, which is vital for producing cells that mature into different types of brain cells, was thinner in mutant organoids. Live cell imaging revealed cells moved through this zone more slowly and circuitously in mutants too. This imaging system, therefore, offers useful insights into brain disease using organoids.

Written by Lux Fatimathas

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.