BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Bone Builders

Activating the Notch signalling pathway is a promising route to treating reduced bone density

18 March 2022

Bone Builders

As we get older our bones lose density, making them more likely to fracture. Maintaining bone density relies on interactions between different cell types in our bones via the protein Notch. Researchers explore whether injecting adult mice with a protein that binds and activates Notch in bone cells — Dll4(E12) — can increase bone formation. Male mice benefited from this treatment but, because they have less bone surface, females did not. However, when female mice were injected with Dll4(E12) plus a hormone PTH used to treat women with brittle bone disease (osteoporosis) bone density was significantly improved, as revealed through micro-CT of their bones. Compared with untreated bones (far left), and bones treated with either Dll4(E12) or PTH (middle two), females that received both had denser bone (far right). Bone-targeted proteins that activate Notch may therefore prove useful in treating osteoporosis and other conditions that reduce bone density.

Written by Lux Fatimathas

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.