BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Two on the Alzheimer's Plaque Protein - I Nervous Interactions

Insights into the normal role of the protein that accumulates in the brain of Alzheimer's sufferers

02 October 2021

Nervous Interactions

As its name suggests, amyloid precursor protein (APP) is known for the problems caused by its breakdown products, the beta amyloid proteins linked to Alzheimer’s disease, but its actual role in healthy brains has long been an enigma. Recent research found it interacts with members of the important Wnt signalling pathway, and through that may play a role in neuron development. In mice lacking APP, neuron shape is altered, featuring a longer axon, the main nerve fibre, at a certain developmental stage (pictured, top right, compared to a typical neuron, top left). Providing APP restores usual axon length (bottom left), but not if using a version of APP without a section known as its cysteine-rich domain, or CRD (bottom right), suggesting that this region is crucial for the signalling interactions to occur. These latest insights provide novel avenues for research into the roles of APP in neuronal development and degeneration.

Written by Emmanuelle Briolat

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.