BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

What's the Damage?

New technique that allows differently edited genes in cells to be highlighted

31 August 2020

What's the Damage?

Over the past few years, researchers have made huge leaps forward in altering the DNA within cells and living organisms through genetic editing techniques such as CRISPR. But while these technologies should make it possible to add, remove or change genes with pinpoint precision, we’re not quite there yet. These techniques currently have low efficiency, meaning that relatively few cells in a tissue end up being correctly modified, and there's a significant risk of altering the wrong genes or damaging DNA by accident (known as ‘off-target’ effects). Scientists have now developed a clever tool called FIVER, which provides a visual ‘readout’ of genome editing by making cells fluoresce in different colours depending on the kinds of genetic changes that have been made. Knowing exactly which cells have been changed and how is an important step towards more accurate ‘genome surgery’, precisely engineering DNA to prevent or treat genetic disorders.

Written by Kat Arney

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.