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Cancer-fighting Mesh

CAR-T cells - immune cells engineered to specifically attack tumours - retained in the tissue on mesh

04 January 2020

Cancer-fighting Mesh

Nitinol, an alloy of nickel and titanium, is a safe and flexible metal used in numerous medical devices including catheters, bone anchors, and stents. And soon, another device may join the list. The lattice of nitinol pictured is covered in immune cells that have been engineered to fight ovarian cancer. When such meshes were implanted at the site of ovarian tumours in mice, they were flexible enough to conform to the shape of the tumour, and they delivered an abundance of T cells to the tumours improving animal survival. Such engineered T cells have been injected into solid tumours before, but the meshes are thought to be more effective at both retaining the cells at the site and covering a larger area of the tumour. These encouraging results and the fact that nitinol is already widely used in patients should hopefully expedite translation of this research to the clinic.

Written by Ruth Williams

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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