Direct electrical communication is a key part of memory formation and retrieval in flies
These bright green structures are mushroom bodies – tightly-packed collections of nerve cells in the brain of an adult fruit fly. First described more than 150 years ago, they play an important role in learning, particularly around smells, and are often used as a model for human memory-making. Nerve cells in mushroom bodies communicate in two different ways – either through releasing and receiving chemical signals, or by direct electrical connections – but it’s not clear exactly which processes are at work in the mushroom body as memories are made. To find out, researchers removed one of the genes that builds electrical connections between mushroom body cells (known as gap junctions), finding that these flies could no longer learn to associate a particular smell with a mild electrical shock. This shows that direct electrical communication is a key part of memory formation and retrieval in flies, and might be important in human brains too.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.