One reason why some people tend to gain weight more than others is because their bodies aren’t as efficient at converting sugars and fat into energy. The discovery of a set of genes controlling this process could lead to new treatments for obesity and diabetes. We all have ‘good’ brown fat cells that produce a calorie-burning type of protein called UCP1 – seen as the green-stained dots in this picture of a progenitor brown fat cell. Researchers identified genes that can boost or slow down UCP1 production, a bit like a dimmer switch on a light. In future, controlling these genes may allow doctors to increase the activity of brown fat cells, so that they remove sugars from the blood more rapidly or burn more energy stored by ‘bad’ fat cells, making them shrink.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.