Stepping on a sea urchin is very painful. I did it once (Ibiza, 1992) and a good-natured waiter poured vinegar on my heel to take away the pain. I assumed it was just the needle-like spines that hurt. But now – thanks to a team of scientists in Brazil looking into the toxins of Echinometra lucunter (pictured) – I see I was wrong. The researchers found that an enzyme called cathepsin B/X present in the urchin’s spines causes a painful inflammatory response in humans. Not only that, they discovered that this enzyme is also involved in regenerating the urchin’s spines, a hard matrix of calcium and magnesium carbonate, when broken. So there you go, this unforgiving enzyme that provides the urchin with a double whammy: reducing me to tears as a toxin while enabling the urchin to rearm and wait for the next unsuspecting holidaymaker.
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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
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