Sneaking into our bodies is only the first step for parasites. They must then evade the numerous defence mechanisms that seek to destroy them. But if they can find a safe haven to multiply in, before launching a full-scale attack, they can increase their chances of success. And where better to do this than in the very white blood cells that are hunting them? Normally this strategy would end in certain destruction, but parasites containing Chagas disease possess a protein that disrupts white blood cells’ normal defences. This image shows that normal response, as an alarm molecule (stained green and yellow) moves from the main white blood cell body into the control centre called the nucleus (stained red), where it triggers the immune response. It’s the ability to block this process that allows the parasites to establish the disease, which infects about 10 million people throughout Latin America annually.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.